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ISSN Graduate Diploma Podcast

Aug 6, 2018

The sport performance-enhancing effects of caffeine are well-founded, particularly in endurance exercise. In research, such results are commonly presented as mean cohort responses. However, when assessing the individual responses of caffeine on sports performance, the ergogenic effects aren’t quite so pervasive, with a high degree of individual variability. Although some of this variability can be down to the study design, caffeine dosages and sex-specific differences, there is a growing body of work, that the individuality in the response to caffeine metabolism may be down to our genes.


In this episode, I delve into the research on the modifying effects of the CYP1A2 polymorphism and the subsequent results on a 10km time-trial in male athletes.  


In this episode, I’ll cover the history behind the discovery of caffeine, the multiple mechanisms proposed for its ergogenic effects and a review of the recent paper titled: Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes by Guest et al. (2018). As always, I’ll be leaving you with my practical take homes from this research.


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Till next time, stay curious, think critically and never-stop learning